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#ARGX — argenx FB102 Celiac Study Hits Primary Endpoint Despite 13% Share Drop | ThinkSabio
Oct 8, 2026 · ThinkSabio Inc
argenx reported positive Phase 2 results for FB102 in celiac disease, with the study meeting its primary endpoint and showing a statistically significant improvement versus placebo.
🔹 Key Highlights
- 🧬 Primary Endpoint Met: FB102 showed a statistically significant improvement in the villus height-to-crypt depth ratio at Day 78.
- 📊 Statistical Result: p=0.0176 versus placebo.
- 🔬 Additional Measures: Immune-cell density, tissue scores and symptom measures were consistent with the primary result.
- ✅ Safety: No new safety signals were reported.
- 🚀 Next Step: argenx plans to advance FB102 into Phase 3.
- 📉 Stock Reaction: ARGX shares fell 13.4% overnight.
💡 Why It Matters
The positive Phase 2 data supports further development of FB102 in celiac disease, with Phase 3 now planned. However, the sharp share-price decline suggests investors may have been expecting stronger efficacy or a more compelling clinical profile.
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