Top Big Cap Negative News Movers Premarket:  DYN: -27% Following NVS Headlines  NVS: -13% Genetic Muscle Disorder Drug Fails Phase 3 Trial IONS: -10% Ionis partner Novartis announces Lp(a)HORIZON Phase 3 topline results for pelacarsen  SRPT: -10% Following NVS Headlines  BIDU: -8% Downgraded to NEUTRAL @ Arete  RPRX: -8% Following NVS Headlines  AMGN: -6% Downgraded to MARKET PERFORM @ BMO  PTON: -6% Downgraded to UNDERWEIGHT @ MS 08-SEP-2026 09:06 AM ET